A database is an organized collection of data stored as multiple datasets, that are generally stored and accessed electronically from a computer system that allows the data to be easily accessed, manipulated, and updated.
In the context of the therapy development pathway, a registry is a type of database that collects and stores information about a group of individuals, most of whom are living with the same disease.
United States Geological Survey (USGS): What are the differences between data, a dataset, and a database?
NCATS Toolkit for Patient-Focused Therapy Development: Determine Patients’ Needs
Rare Diseases Registry Program (RaDaR): Decide How to Collect & Store Your Data