CRISPR–Cas gene editing system is a group of gene editing tools composed of a short strand of RNA, often called guide RNA (gRNA), that is made to target a specific sequence of DNA. The gRNA strand is surrounded by short repeated sequences of RNA that act as scaffolding. The system is linked to an enzyme (Cas protein) that is capable of cutting double-stranded DNA.

Note: CRISPR stands for “clustered regularly interspaced short palindromic repeats” and Cas stands for “CRISPR associated protein”.

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National Human Genome Research Institute: What is genome editing?
U.S. National Library of Medicine (NLM) MedlinePlus: What are genome editing and CRISPR-Cas9?
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NCATS Toolkit for Patient-Focused Therapy Development: Genetic Therapeutics
Wellcome Genome Campus YourGenome: What is CRISPR-Cas9?